Faculty members of the Cardiovascular Research Center had an outstanding and very productive year. Below is a listing of all of the publications, book chapters and other news of note for 2005:

Peer Reviewed Journal Articles

1. Kaiser RA, Liang Q, Bueno O, Huang Y, Lackey T, Klevitsky R, Hewett TE, Molkentin JD. Genetic inhibition or activation of JNK1/2 protects the myocardium from ischemia-reperfusion-induced cell death in vivo. J Biol Chem. 2005;280:32602-8.

2. Kuzman JA, Gerdes AM, Kobayashi S, Liang Q. Thyroid hormone activates Akt and prevents serum starvation-induced cell death in neonatal rat cardiomyocytes. J Mol Cell Cardiol. 2005;39:841-4.

3. Tang YD, Kuzman JA, Said S, Anderson BE, Wang X, Gerdes AM. Low thyroid function leads to cardiac atrophy with chamber dilatation, impaired myocardial blood flow, loss of arterioles, and severe systolic dysfunction. Circulation. 2005;112:3122-30.

4. Chen Q, Liu JB, Horak KM, Zheng H, Kumarapeli AR, Li J, Li F, Gerdes AM, Wawrousek EF, Wang X. Intrasarcoplasmic amyloidosis impairs proteolytic function of proteasomes in cardiomyocytes by compromising substrate uptake. Circ Res. 2005;97:1018-26.

5. Khalife WI, Tang YD, Kuzman JA, Thomas TA, Anderson BE, Said S, Tille P, Schlenker EH, Gerdes AM. Treatment of subclinical hypothyroidism reverses ischemia and prevents myocyte loss and progressive LV dysfunction in hamsters with dilated cardiomyopathy. Am J Physiol Heart Circ Physiol. 2005;289:H2409-15.

6. Kuzman JA, Thomas TA, Vogelsang KA, Said S, Anderson BE, Gerdes AM. Effects of induced hyperthyroidism in normal and cardiomyopathic hamsters. J Appl Physiol. 2005;99:1428-33.

7. Kuzman JA, Vogelsang KA, Thomas TA, Gerdes AM. L-Thyroxine activates Akt signaling in the heart. J Mol Cell Cardiol. 2005;39:251-8.

8. Johnsen DD, Kacimi R, Anderson BE, Thomas TA, Said S, Gerdes AM. Protein kinase C isozymes in hypertension and hypertrophy: insight from SHHF rat hearts. Mol Cell Biochem. 2005;270:63-9.

9. Thomas TA, Kuzman JA, Anderson BE, Andersen SM, Schlenker EH, Holder MS, Gerdes AM. Thyroid hormones induce unique and potentially beneficial changes in cardiac myocyte shape in hypertensive rats near heart failure. Am J Physiol Heart Circ Physiol. 2005;288:H2118-22.

10. Yi XP, Zhou J, Baker J, Wang X, Gerdes AM, Li F. Myocardial expression and redistribution of GRKs in hypertensive hypertrophy and failure. Anat Rec A Discov Mol Cell Evol Biol. 2005;282:13-23.

11. Kumarapeli AR, Horak KM, Glasford JW, Li J, Chen Q, Liu J, Zheng H, Wang X. A novel transgenic mouse model reveals deregulation of the ubiquitin-proteasome system in the heart by doxorubicin. FASEB J. 2005;19:2051-3.

12. Yen CY, Helmke SM, Cios KJ, Perryman MB, Duncan MW. Quantitative analysis of proteomics using data mining. An automated system for constructing assays quickly and precisely. IEEE Eng Med Biol Mag. 2005;24:67-72.

13. Kobayashi S, Lackey T, Huang Y, Bisping E, Pu WT,  Boxer LM, Liang Q.  Transcription factor Gata4 regulates cardiac Bcl2 gene expression In Vitro and In Vivo. FASEB J (In Press).

14. Yi XP, J Zhou, L Huber, J Qu, X Wang, AM Gerdes, F Li.  Nuclear compartmentalization of FAK and FRNK in cardiac myocytes. Am J Physiol (In Press).

15. Liu JB, Chen Q, Huang W, Horak KM, Zheng H, Mestril R, Wang X.  Impairment of the ubiquitin-proteasome system in desminopathy mouse hearts. FASEB J 2005 (In Press)  

16. Liu J-B, Tang M, Mestril R, Wang X. Aberrant protein aggregation is essential for a mutant desmin to impair the proteolytic function of the ubiquitin-proteasome system in cardiomyocytes. J Mol Cell Cardiol 2005 (in press)

17. Gard JJ, Yamada K, Green KG, Eloff BC, Rosenbaum DS, Wang X, Robbins J, Schuessler RB, Yamada KA, Saffitz JE. Remodeling of gap junctions and slow conduction in a mouse model of desmin-related cardiomyopathy.Cardiovasc Res 2005; 67(3): 539-547.

18. O’Connell TD, Swigart PM, Rodrigo MC, Ishizaka S, Joho S, Turnbull L, Tecott LH, Baker AJ, Foster E, Grossman W, Simpson PC. á1-Adrenergic receptors prevent a maladaptive cardiac response to pressure overload. J Clin Invest (In Press)

Book chapters

1. Armstrong, SC  2005. Analysis of MAP kinase activation. In: Mast Cells: Methods and Protocols, G. Krishnaswamy and DS Chi (Eds) Methods in Molecular Biology Humana Press 315:153-165.

Other news of note

1. Based on internet downloads, Dr. Wangs 2004 article in J Mol Cell Cardiol made the list for “hottest 25 papers” for that journal

Congratulations to all of the investigators and staff involved!