Education
- PhD, Microbiology - Texas A & M, College Station, TX
- MS, Microbiology - University of Montana, Missoula, MT
- BSc, Biology - Emory University, Atlanta, GA
Experience
- April 2004-Present, Executive Director, South Dakota Health Research Foundation
- 2003-Present Professor and Assistant Director, Cardiovascular Research Center, South Dakota Health Research Foundation and University of South Dakota School of Medicine and Health Sciences.
- 1996-2001 Director, Technology Transfer Office, University of Colorado Health Sciences Center, Denver, Colorado
- 1996-2003 Professor, Department of Medicine, Division of Cardiology, and Cellular and Developmental Biology, Director, Molecular Cardiology, University of Colorado Health Sciences Center, Denver, Colorado
- 1992-1996 Associate Professor, Department of Medicine, Division of Cardiology, and Cellular and Developmental Biology, Director, Molecular Cardiology, University of Colorado Health Sciences Center, Denver, Colorado
- 1990-1992 Associate Professor, Department of Medicine, Director, Molecular Cardiology Unit, Baylor College of Medicine, Houston, TX
- 1983-1990 Assistant Professor, Department of Medicine, Director, Molecular Cardiology Unit, Baylor College of Medicine, Houston, Texas
- 1982-1991 Director, Creatine Kinase Laboratory, The Methodist Hospital, Houston, Texas
- 1982-1983 Instructor, Department of Medicine, Baylor College of Medicine, Houston, Texas
- 1981-1982 Research Associate, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri
- 1980-1981 Research Associate, Department of Microbiology, University of Illinois, Urbana, Illinois
- 1978-1980 Graduate Research Associate, Department of Biology, Texas A&M University, College Station, Texas
- 1975-1977 Graduate Research Associate, Department of Veterinary Microbiology, Texas A&M University, College Station, Texas
- 1974-1975 Research Associate, Department of Medicine, University of Texas Health Science Center, Dallas, Texas
- 1972-1974 Graduate Research Associate, Department of Microbiology, University of Texas Health Science Center, Dallas, Texas
- 1971-1972 Graduate Research Associate, Department of Microbiology, University of Montana, Missoula, Montana
Distinctions
- Currently on the National Board of Directors for the American Heart Association
- Served on numerous grant review committees for the American Heart Association and the National Institutes of Health
- Currently holds three patents
- One of four founding scientists for Myogen, Inc., a publicly traded biotechnology company located in Westminster, Colorado
- Number of publications 65
Research Focus
- Characterizing the populations of proteins present in normal and failing hearts
- Studying the function of a specific protein which regulates the size and shape of heart muscle cells
- Searching for the defective gene that causes hypoplastic left heart syndrome, a birth defect that interferes with normal heart development
Professional Societies and other Professional Activities
- American Association for the Advancement of Science
- American Heart Association, Basic Science Council
- Association of University Technology Managers
- Association of University Related Research Parks
- 2002-2004 Member, National Research Committee, AHA, Dallas, TX
- 2002-2004 Member, National Board of Directors, AHA, Dallas, TX.
- 2002 Member, Special PPG Study Section NIH
- 2001 Temporary Member, Cardiovascular Study Section A, NIH
- 2001-2002 President, Desert-Mountain AHA Affiliate
- 2001-2002 Chairman, National AHA Peer Review Steering Committee
Current Grant Funding
- Agency: NIH/NHLBI RO1HL64136-01
Principal Investigator: M. Benjamin Peryman for a project entitled "Myocardial myotonic dystrophy protein kinase function"
Funding dates 4/1/01-3/31/05
Total direct costs: $875,000
The goals of the project are to identify the substrates and interacting proteins for human myotonic dystrophy protein kinase.
- Agency: NIH- COBRE
Mechanisms of cardiovascular remodeling.
Principle Investigator: Anthony Martin Gerdes
Funding dates: 9/1/02-8/3/07
Total direct costs: $7,999,190
25% time and effort
The goals of the project is to define the mechanisms of cardiovascular remodeling in heart failure.
- Agency-State of SD 2010 Program
South Dakota Signal Transduction Center
7/1/2004-6/30/2009
$4,500,000
Publications, recent
- Helmke, S.M., Yen, C-Y., Cios, K.J., Nunley, K., Bristow, M.R., Duncan, M.W., Perryman, M.B. Simultaneous quantification of human cardiac a-and b-myosin heavy chain proteins by MALDI-TOF mass spectrometry. Anal. Chem. 76 1683-1689. 2004
Krenz, M., Sanbe, A., Bouyer-Dalloz, F., Gulick, J., Klevitsky, R., Hewett, T.E., Osinka, H.E., Lorenz, J.N., Brosseau, C., Frederico, A., Alpert, N.R., Warshaw, D. M., Perryman, M. B., Helmke, S.M., Robbins, J. Analysis of myosin heavy chain functionality in the heart. J. Biol. Chem. 278 17466-17474. 2003
Bohlmeyer, T.J., Helmke, S., Ge, S., Fox, J., Brodsky, G., Sederberg, J.H., Robinson, A.D., Minobe, W., Bristow, M.R.,Perryman, M.B. Hypoplastic left heart syndrome myocytes are differentiated but possess a unique phenotype. Cardiovasc. Path. 12 26-31, 2003
Asano, K., Bohlmeyer, T.J., Wescott, J.Y., Zisman, L.S., Kinugawa, K., Good, M., Minobe, W.A., Roden, R.L., Wolfel, E.E., Lindenfeld, J., Port, J.D., Perryman, M.B., Clevland, J., Lowes, B.D., and Bristow, M.R., Altered expression of endothelin receptors in failing human left ventricles. J. Mol. Cell Cardiol. 34 833-846, 2002
Mounsey, P.J., John, J.E., Helmke, S.M., Bush, E.W., Gilbert, J., Roses, A.D., Perryman, M.B., Jones, L.R., and Moorman, J.R., Phosholemman is a substrate for myotonic dystrophy protein kinase. J. Biol. Chem. 275. 23362-23367, 2000
Bush, E.W., Helmke, S.M., Birnbaum, R.A., and Perryman, M.B., Myotonic dystrophy kinase domains mediate localization, oligomerization, novel catalytic activity and autoinhibition. Biochemistry 39. 8420-8490, 2000
Zisman, L.S., Asano, K., Dutcher, D.L., Ferdensi, A., Robertson, A.D., Jenkin, M., Bush, E.W., Bohlmeyer, T, Perryman, M.B., and Brstow, M.R., Differential regulation of cardiac angiotensin converting enzyme (ACE) binding sites and AT1 receptor density in the failing heart. Circulation 98. 1735-1741, 1998.
Pahl, P.M.B., Hodges, Y.K., Meltesen, L., Perryman, M.B., Horwitz, K.B., and Horwitz, L.D. ZNF207, a ubiquitously expressed zinc finger gene on chromosome 6p21.3. Genomics 53. 410-412, 1998.
Steegs, K., Heerschap, A., de Haan, A., Ruitenbeek W., Oerlemans, F., van Deursen, J., Perryman, B., Pette, D., Bruckwilder, M., Koudijs, J., Jap, P., Wieringa, B. Use of gene targeting for compromising energy homeostasis in neuro-muscular tissues: The role of sarcomeric mitochondrial creatine kinase. J. Neurosci. Meth. 71. 29-41, 1997.
Steegs, K., Benders, A., Oerlemans, F., deHaan, A., Heerschap, A., Ruitenbeek, W., Jost, C., van Deursen, J., Perryman, M.B., Pette, D., Bruckwilder, M., Koudijis, Jap, P., Veerkamp, J. and Wieringa, B. Altered Ca2+ responses in muscles with combined mitochondrial and cytosolic creatine kinase deficiencies. Cell 89. 93-103, 1997.
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