Education
- 1987 – Post doctoral fellowship, Yale University – New Haven, CT
- 1982 – Ph.D., Cell and Developmental Biology, University of Arizona – Tucson, AZ
- 1978 – M.S., Genetics, University of Arizona – Tucson, AZ
- 1975 – B.S., Zoology, University of Wyoming – Laramie, WY
Experience
- Director - Cancer Biology Research Center, Sanford Research/USD, Sioux Falls, SD, July 2006-present
- Professor - Division of Basic Biomedical Sciences, Sanford School of Medicine, Vermillion, SD, July 2002-present
- Associate Professor - Department of Biochemistry and Molecular Biology, Sanford School of Medicine, Vermillion, SD, July 1996-June 2002
- Assistant Professor - Department of Biochemistry and Molecular Biology, Sanford School of Medicine, Vermillion, SD, July 1991-June 1996
- Assistant Professor - Department of Biological Sciences, University of South Carolina, Columbia, SC, December 1987-May 1991
- Postdoctoral Fellow - Department of Biology, Yale University, New Haven, CT January 1984-December 1987
- Postdoctoral Fellow - Department of Cellular and Developmental Biology, University of Arizona, Tucson, AZ, December 1982-December 1983
- Predoctoral Student - Department of Cellular and Developmental Biology, University of Arizona, Tuscon, AZ, January 1979-December 1982
Publications
- Wei, Q., Eviatar-Ribak T, Miskimins W.K. and Miskimins R. Galectin-4 is involved in p27-mediated activation of the MBP promoter. J. Neurochem. 2006, in press.
Wei Q, Miskimins W.K., and Miskimins R. Stage-specific expression of myelin basic protein in oligodendrocytes involves Nkx2.2-mediated repression that is relieved by the Sp1 transcription factor. J. Biol. Chem. 280:16284-16294, 2005.
Wei, Q., Miskimins, W.K., and Miskimins, R. Sox10 Acts as a Tissue-Specific Transcription Factor Enhancing Activation of the Myelin Basic Protein Gene Promoter by p27Kip1 and Sp1. J. Neurosci. Res., 78:796-802, 2004.
Wang, G., Miskimins, R., and Miskimins, W.K. Regulation of p27Kip1 by intracellular iron levels. BioMetals, 17:15-24, 2004
Wang, G., Reisdorph, R., Clark, R.E., Jr., Miskimins, R., Lindahl, R., and Miskimins, W.K. Cyclin dependent kinase inhibitor p27Kip1 is upregulated by hypoxia via an ARNT dependent pathway. J. Cell. Biochem., 90:548-60, 2003.
Jiang, H., Coleman, J., Miskimins, R., and Miskimins, W.K. Expression of constitutively active 4EBP-1 enhances p27Kip1 expression and inhibits proliferation of MCF7 breasr cancer cells. Cancer Cell International, 3:2, 2003.
Wei, W., Miskimins, W.K. and Miskimins, R. The Sp1 family of transcription factors is involved in p27Kip1-mediated activation of myelin basic protein gene expression. Mol. Cell. Biol., 23:4035-4045, 2003.
Wei, Q., Miskimins, W.K. and Miskimins, R. Cloning and characterization of the rat myelin basic protein gene promoter. Gene, 313:161-167, 2003.
Clark, R.E., Miskimins, W.K. and Miskimins, R. PI3-kinase p85 enhances expression from the myelin basic protein promoter in oligodendrocytes. J. Neurochem., 83:565-573, 2002.
Clark, R.E., Miskimins, W.K. and Miskimins, R. Cyclic AMP inducibility of the myelin basic protein gene promoter requires the NF1 site. Int. J. Dev. Neurosci., 20:103-111, 2002.
Miskimins, R.,, Srinivasan, R., Marin-Husstege, M., Miskimins, W.K. and Casaccia-Bonnefil, P. (2002) p27Kip1 enhances myelin basic protein gene promoter activity. J. Neurosci. Res. 67:100-105.
Coleman, J., Hawkinson, M., Miskimins, R. and Miskimins, W.K. (2001)The major transcription initiation site of the p27Kip1 gene is conserved in human and mouse and produces a long 5' UTR. BMC Molecular Biology 2:12.
Miskimins, W.K., Wang, G., Hawkinson, M. and Miskimins, R. (2001) Control of cyclin-dependent kinase inhibitor p27 expression by cap-independent translation. Mol. Cell. Biol. 21:4960-4967.
Miskimins, R. and Miskimins, W.K. (2001) A role for an AP-1-like site in the expression of the myelin basic protein gene during differentiation. Intl. J. Dev. Neurosci. 19:85-91.
Wang, G., Miskimins, R. and Miskimins, W.K. (2000) Mimosine arrests cells in G1 by enhancing the levels of p27kip1. Exp. Cell Research. 254:64-71.
Wang, G., Miskimins, R. and Miskimins, W.K. (1999) The cyclin dependent kinase inhibitor p27kip1 is localized to the cytosol in Swiss/3T3 cells. Oncogene, 18:5204-5210.
Moore, B.A., Miskimins, R. and Miskimins, W.K. (1999) Involvement of ATF-1 in the induction of the transferrin receptor promoter in response to UV irradiation in B16 melanoma cells. Mol. Cell Biol. Res. Comm. 1:1-6.
Boesch, J.S., Miskimins, R., Miskimins, W.K. and Lindahl, R. (1999) Identification of elements responsible for constitutive expression of the aldehyde dehydrogenase-3 gene in rat cornea. Arch. Bioch. Biophys., 361:223-230.
Clark, R., Stewart, M., Miskimins, W.K. and Miskimins, R. (1998) Involvement of MAP kinase in the cyclic AMP induction of myelin basic protein gene expression. Int. J. Dev. Neurosci., 16:323-331.
Friessen, A.J., Miskimins, W.K. and Miskimins, R. (1997) The cdk inhibitor p27kip1 is expressed at high levels in cells that express a myelinating phenotype. J. Neurosci. Res., 50:373-382.
Miskimins, W.K., King, F. and Miskimins, R. (1997) Phosphatidylinositol 3- kinase inhibitor wortmannin blocks mitogenic activation of the transferrin receptor gene promoter in late G1. Cell Growth and Differentiation, 8:565-570.
Hirsch, S., Miskimins, R. and Miskimins, W.K. (1996) Mitogenic activation of the transferrin receptor gene promoter is modulated by inhibitors of tyrosine kinases and tyrosine phosphatases. Receptors and Signal Transduction, 6:121-129.
Xie, Y.Q., Takimoto, K., Pitot, H.C., Miskimins, W.K. and Lindahl, R. (1996) Characterization of the rat class 3 aldehyde dehydrogenase gene promoter. Nucleic Acids Res. 21:4185-4191.
Hirsch, S. and Miskimins, W.K. (1995) UV light and serum induce similar delayed responses that lead to activation of a mitogen-responsive promoter. Cell. and Mol. Biol. Res., 41:441-449.
Hirsch, S. and Miskimins, W.K. (1995) Mitogen induction of nuclear factors that interact with a delayed responsive region of the transferrin receptor gene promoter. Cell Growth and Differentiation, 6:719-726.
Ouyang, Q., Bommakanti, M. and Miskimins, W.K. (1993) A mitogen-responsive promoter region that is synergistically activated through multiple signalling pathways. Mol. Cell Biol., 13:1796-1804.
Miskimins, W.K. (1992) Interaction of multiple factors with a GC-rich element within the mitogen responsive region of the human transferrin receptor gene. J. Cell. Biochem., 49:349-356.
Ouyang, Q. and Miskimins, W.K. (1992) A supercoil-dependent structural alteration within the regulatory region of the human transferrin receptor gene. Biochem. Biophys. Res. Comm., 183:62-69.
Brown, D.B., Miskimins, W.K. and Ruddle, F.H. (1991) Partial purification of Xenopus laevis egg extract factor(s) that induce swelling in permeabilized human sperm. J. Exp. Zool., 258:263-272.
Miskimins, W.K. and Brown, D.B. (1990) Analysis of cis-acting promoter elements using microinjected synthetic oligonucleotides. Exp. Cell Res., 191:328-331.
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