mgerdes@usd.edu
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Education
• BS, Biology -Lamar University
• PhD, Anatomy -University of Texas at Galveston

Professional and Research Experience
• Senior Scientist and Director and Founder of the Cardiovascular Research Center, Sanford Research/USD, Sioux Falls, January 1998- present
• Professor, Basic Biomedical Sciences and Dept. of Internal Medicine, University of South Dakota School of Medicine and Health Sciences, Sioux Falls, SD Jan. 1993 to present
• Professor and Chairman with tenure, Dept. of Anatomy and Structural Biology, University of South Dakota, Vermillion, SD, January 1993-July 1998
• Associate Prof. of Medicine, joint appt, Dept. Internal Medicine (Cardiology), Univ. S. Florida., Tampa, FL July 1990-December 1992
• Visiting Scientist, Division of Cardiology, Univ. of Cincinnati, Cincinnati, OH, January 1991-July 1991
• Associate Prof. with tenure, Dept. of Anatomy, Univ. South Florida, Tampa, FL, September 1988-December 1992
• Visiting Scientist, Physiologisches Institut, Universitat Munchen, West Germany, February 1988-May 1988
• Assistant Prof., Department of Anatomy, University of South Florida, Tampa, FL, July 1982-August 1988
• Res. Assistant Prof., Dept. of Pathology, University of Alabama, Birmingham, July 1980-June 1982
• Postdoctoral Fellow, NIH CV Training Grant, L.S.U. Medical Center, New Orleans, LA, September 1978-July 1980

Distinctions
• Pioneer in the field of remodeling of cardiac myocytes in cardiac hypertrophy and congestive heart failure
• Number of publications 87

Research Focus
• "Identification of key cellular and molecular mechanisms of heart failure and identification of new therapies for more effective treatment of this syndrome"

Professional Societies
• American Physiological Society
• American Heart Association (Basic Council)- Fellow of the American Heart Association
• International Society for Heart Research
• Heart Failure Society of America

Awards, Professional Appointments, and Membership on Editorial Boards
• Member of the Editorial Board of the following journals: Journal of Molecular and Cellular Cardiology, American Journal of Physiology: Cardiovascular Section, and the Journal of Cardiac Failure.
• Fellow of the Cardiovascular Section of the American Physiological Society
• Fellow of the Council of Basic Cardiovascular Sciences of the American Heart Association (FAHA)
• American College of Cardiology 48th Annual Scientific Session, presentation was among 40 selected for a CD-ROM compilation of the "best presentations and findings from the 1999 Annual Meeting".
• South Dakota Board of Regents Award for Excellence in Research, 2000.
• Fellow of the Council of Basic Cardiovascular Sciences of the Am. Heart Assoc. (FAHA)
• Finalist, Best Abstract Award, ISHR Meeting, July 24-27, 2002
• Satellite Conference for the World Congress ISHR meeting, July 12-15, 2001, Minneapolis, MN, (Member of Conference Organizing Committee).
• World Congress of the International Society for Heart Research, July 6-11, 2001, Winnipeg, Canada, received "Medal of Merit".
• Heart Failure Society of America, Annual Meeting, 2002, 2003, 2004, Abstract Grader.

Current Grant Funding
• South Dakota Health Research Foundation- Support for Cardiovascular Research Center. 4/1/98-3/31/08, $310,000/year, P.I.
• Myocyte remodeling in heart failure. NIH, 7/1/00-6/30/05, $1,756,250, P.I.
• Mechanisms of cardiovascular remodeling. NIH-COBRE, 9/1/02-8/31/07, $9,536,883 (total costs), PI.
• State of South Dakota 2010 Program. South Dakota Signal Transduction Center. 7/1/2004-6/30/2009, $4,500,000, PI.

Publications (selected)
• Kuzman, JA, TD O'Connell, AM Gerdes. Rapamycin prevents thyroid hormone induced cardiac hypertrophy. Endocrinology (In Press)
  
  Kuzman, JA, Y Tang, KA Vogelsang, S Said, BE Anderson, E Morkin, AM Gerdes. Thyroid hormone analog, DITPA, exerts beneficial effects on chamber and cellular remodeling in cardiomyopathic hamsters. Can J Physiol Pharm (In Press)
  
  Schultz RL, JG Swallow, RP Waters, JA Kuzman, RA Redetzke, S Said, AM Gerdes. Effects of excessive long-term exercise on cardiac myocyte remodeling in hypertensive heart failure prone rats. Hypertension (In Press)
  
  Zhou J, J Qu, X Ping, K Graber, L Huber, X Wang, AM Gerdes, F Li. Up-regulation of γ-catenin compensates for the loss of β-catenin in adult cardiomyocytes. Am J Physiol 292:H270-76, 2007.
  
  Yi XP, J Zhou, L Huber, J Qu, X Wang, AM Gerdes, F Li. Nuclear compartmentalization of FAK and FRNK in cardiac myocytes. Am J Physiol 290:H2509-15, 2006.
  
  Liang Q, A Elson, AM Gerdes. P38 MAP kinase activity is correlated with angiotensin II type 1 receptor blocker-induced left ventricular reverse remodeling in Spontaneously Hypertensive Heart Failure rats. J Cardiac Failure 12:479-486, 2006.
  
  Chen Q, JB Liu, KM Horak, H Zheng, ARK Kumarapeli, J Li, F Li, AM Gerdes, EF Wawrousek, X Wang. Intrasarcoplasmic amyloidosis impairs proteolytic function of proteasomes in cardiomyocytes by compromising substrate uptake. Circ Res 97:1018-1026, 2005.
  
  Kuzman, JA, AM Gerdes, S Kobayashi, Q Liang. Thyroid Hormone Activates Akt and Prevents Serum Starvation Induced Cell Death in Neonatal Rat Cardiomyocytes. J Mol Cell Cardiol 39:841-844, 2005.
  
  Khalife WI, YD Tang, JA Kuzman, TA Thomas, BE Anderson, S Said, P Tille, EH Schlenker, AM Gerdes.  Treatment of sub-clinical hypothyroidism reverses myocardial ischemia and prevents myocyte loss and progressive ventricular dysfunction in hamsters with dilated cardiomyopathy. Am J Physiol 289:H2409-H2415, 2005. Selected by NIH as “Science Advance” for Congressional report.
  
  Tang, YD, JA Kuzman, S Said, BE Anderson, X Wang, AM Gerdes.  Low thyroid function leads to cardiac atrophy with chamber dilatation, impaired myocardial blood flow, loss of arterioles, and severe systolic dysfunction. Circulation 112:3122-3130, 2005.  Selected by NIH as “Science Advance” for Congressional report.
  
  Gerdes AM, Kellerman SE, Moore JA, Clark LC, Reaves PY, Malec KB, Muffly KE, McKeown PP, Schocken DD (1992). Structural remodeling of cardiac myocytes from patients with chronic ischemic heart disease. Circulation 86:426-430.
    – First study to show that excessive myocyte lengthening from series sarcomere formation is the primary cause of chamber dilation in heart failure. A figure from this paper now appears in many cardiology texts.
  
  Onodera, T, T Tamura, S Said, SA McCune, AM Gerdes (1998) Maladaptive remodeling of cardiac myocyte shape begins long before failure in hypertension. Hypertension 32:753-757.
    – First study to show that excessive myocyte lengthening begins long before the onset of symptoms of heart failure and is likely the most important early remodeling event triggering progression to failure.
  
  Tamura, T, S Said, J Harris, W Lu, AM Gerdes (2000). Reverse remodeling of cardiac myocyte hypertrophy and failure by targeting the renin-angiotensin system. Circulation 102:245-259.
    – First study to show that it is possible to reverse maladaptive myocyte remodeling in heart failure nearly back to normal with drug treatment. Received international media attention and was featured on cover.
  
  Thomas TA, JA Kuzman, BE Anderson, SM Andersen, EH Schlenker, MS Holder, AM Gerdes. Thyroid hormones induce unique, potentially beneficial, change in cardiac myocyte shape in hypertensive rats near heart failure. Am J Physiol (In Press)
  
  Johnsen DD, R Kacimi, BE Anderson, TA Thomas, S Said, AM Gerdes. Protein Kinase C Isozymes: Insight from SHHF rat hearts. Mol Cell Biochem (In Press)
  
  hou J, Gerdes AM, Wang X, Li F. Myocardial expression and redistribution of GRKs in hypertensive hypertrophy and failure. Anat Rec (In Press)
  
  Dong X, L Jinbao, H Zheng, JW Glasford, W Huang, QH Chen, NR Harden, F Li, AM Gerdes, X Wang. In situ dynamically monitoring the proteolytic function of the Ubiquitin-Proteosome system in cultured cardiac myocytes. Am J Physiol 287:H1417-H1425, 2004.
  
  Gaustad KG, AC Boquest, BE Anderson, AM Gerdes, P Collas. Differentiation of human adipose tissue stem cells using extracts of rat cardiomyocytes. Biochem Biophys Res Co 314:420-427, 2004.
  
  Li F, X Wang, XP Yi, AM Gerdes. Structural basis of ventricular remodeling: Role of the myocyte. Current Heart Failure Reports 1:5-8, 2004.
  
  Schlenker EH, T Tamura, J Boles, AM Gerdes: Sex-specific effects of thyroid hormones on cardiopulmonary function in SHHF rats. J Appl Physiol 95:2292-2298, 2003.
  
  Yi XP, X Wang, AM Gerdes, F Li: Subcellular redistribution of FAK and FRNK in hypertrophic myocardium. Hypertension 41:1317-1323, 2003 (featured on cover).
  
  Kim YK, S Mankad, SJ Kim, G Takagi, T Tamura, AM Gerdes, SP Bishop, CM Kramer: Adding angiotensin II type 1 receptor blockade to angiotensin converting enzyme inhibition limits myocyte remodeling after myocardial infarction. J Cardiac Failure 9:238-245, 2003.
  
  R Kacimi, AM Gerdes: Alterations in G protein and MAP kinase signaling pathways during cardiac remodeling in hypertension and heart failure. Hypertension 41:968-977, 2003.
  
  Wang XJ, H Osinska, R Klevitsky, AM Gerdes, M Nieman, J Lorenz, T Hewett, J Robbins: Expression of R120G-ÜB-Crystallin causes aberrant desmin and ÜB-Crystallin aggregation and cardiomyopathy in mice. Circ Res 89:84-91, 2001.
  
  Wang X, H Osinska, GW Dorn II, JN Lorenz, R Klevitsky, AM Gerdes, TE Hewett, S Witt, T Kimball, J Gulick, J Robbins: A transgenic mouse model of desmin-related cardiomyopathy. Circulation 103:2402-2407, 2001.