Meena.Jaggi@usd.edu

Education
• Ph.D Central Drug Research Inst., Lucknow, India, 1998 – Reproductive Biology
• M.Sc University of Allahabad, India, 1990 – Zoology, Cytogenetics
• B.Sc University of Allahabad, India, 1988 – Botany, Chemistry, Zoology

Experience
• Assistant Professor, Dept. of Basic Biomedical Sciences, The University of South Dakota Sanford School of Medicine, Sioux Falls, SD, 2006-Present
• Assistant Professor, Dept. of Obstetrics & Gynecology, The University of South Dakota Sanford School of Medicine, Sioux Falls, SD, USA 2006-Present
• Research Scientist, Signal Transduction Institute, South Dakota Health Research Foundation, Sioux Falls, SD, 2005-Present
• Instructor, Department of Surgery, Nebraska Medical Center, Omaha, NE, 2002-2005
• Postdoctoral Research Associate, Department of Oral Biology, Nebraska Medical Center Omaha, NE, 2001-2002
• Postdoctoral Fellow, Department of Biology, University of Toledo, Toledo, OH, 1999-2001
• Research Associate, Department of Biochemistry, All India Institute of Medical Sciences (AIIMS), New Delhi, INDIA, 1998-1999
• SRF, Department of Endocrinology, CDRI, Lucknow, INDIA, 1995-1998
• JRF, Department of Endocrinology, CDRI, Lucknow, INDIA, 1993-1995

Professional Memberships
• 2002 - Member, The American Society for Cell Biology
• 2003 - Member, The American Association for Cancer Research

Honors and Awards
• 1995 - Senior Research Fellowship awarded by Ministry of Health and Family Welfare, G.O.I at C.D.R.I. Lucknow, India
• 1993 - Junior Research Fellowship awarded by Ministry of Health and Family Welfare, G.O.I. at C.D.R.I. Lucknow, India
• 1993 - Qualified GATE Examination, (Discipline-General Sciences) Conducted by Ministry of Human Resource Development, India

Research Support
• SDBOR-2010-02-05   (Jaggi - New Faculty)   7/1/2004 - 6/30/2009
  South Dakota State Legislature, Governor's 2010 Initiative
  South Dakota Signal Transduction Center.
  The goal of this project is to establish research infrastructure and to support four individual projects to characterize the role altered signal transduction pathways in human disease.
• W81XWH-05-1-0045   M. Jaggi, (Collaborator)   10/2004 - 09/2007
  Department of Defense
  MT 2A Phosphorylation by PKC Mu/PKD Influences Chemosensitivity to Cisplatin in Prostate Cancer
  Study focus is on MT 2A expression and its contribution to Cisplatin resistance.
• 408020   M. Jaggi, PI   04/01/06-03/31/07
  University of South Dakota Internal Research Program
  Cellular functions of PKD1/E-cadherin interaction in prostate cancer.
  To study the nature of E-Cadherin and PKD1 interaction and effect on the cancer cell.
• P20 RR016479   M. Jaggi, PI (Pilot Project)   07/01/06-06/30/07
  NIH, NCRR
  Effect of OKD1 and ß-catenin interaction on proliferation of prostate cancer cells.
  To determine the effect of PKD1 knock-down on ß-catenin subcellular localization and Wnt signaling.

Publications
• 1. Jaggi M., Du C., Zhang W., and Balaji K. C. Protein Kinase D1: A Protein of Emerging Translational Interest. In Press in Frontiers in Bioscience.
  
  2. Smith D. J., Jaggi M., Zhang W., Galich A. N., Sterrett S. P., Smith L. M., and Balaji K. C., Methallothioneins and Resistance to Cisplatin and Radiation in Prostate Cancer. In Press in Urology.
  
  3. Jaggi M., Nazemi T., Baker J. J., Galich A. N., Smith L. M., and Balaji K. C. N-cadherin Switching Occurs in High Gleason Grade Prostate Cancer. Prostate, 2006; 66(2): 193-199.
  
  4. Jaggi M., Johansson S. L., Smith L. M., Baker J. J., Galich A. N., Balaji K. C. Aberrant Expression of E-Cadherin and Beta-Catenin in Human Prostate Cancer. Urological Oncology, 2005, 23(6): 402-406.
  
  5. Lewis T., Milam T., Rao P., Jaggi M., Smith D., Hemstreet G., Balaji K. C., Tissue Transglutaminase Interacts with AKAP 13 in Prostate Cancer. Urological Oncology, 2005, 23(6): 407-412.
  
  6. Jaggi M., Rao P. S., Smith D. J., Wheelock M. J. and Johnson K.R, Hemstreet G. P. and Balaji K. C. E-cadherin Phosphorylation by PKD1/PKC mu is Associated with Altered Cellular Aggregation and Motility in Prostate Cancer. Cancer Research, 2005 65(2): 483-492.
  
  7. Rao P. S., Jaggi M., Smith D. J., Hemstreet G. P. and Balaji K. C. Metallothionein 2A interacts with the kinase domain of PKCmu in prostate cancer. Biochem Biophys Res Commun. 2003, 310(3): 1032-1038.
  
  8. Jaggi M., Rao P. S., Smith D. J., Hemstreet G. P. and Balaji K. C. Protein kinase C mu is down-regulated in androgen-independent prostate cancer. Biochemical and Biophysical Research Communications, 2003; 307(2): 254-260.
  
  9. Jaggi M, Wheelock M. J and Johnson K.R. Differential displacement of classical cadherins by VE cadherin. Cell Communication and Adhesion, 2002, 9(2): 103-115.
  
  10. Jaggi M., Farheen S., and Mehrotra P.K. Use of differentiating human trophoblast in in vitro assay. In Vitro Cell Dev Biol Anim., 1999, 35(8): 427-430.
  
  11. Jaggi M., Mehrotra P. K., Maitra S. C., Agarwal S. L., and Das K. Ultrastructure of intermediate trophoblast cells during morphogenesis of syncytiotrophoblast in human early pregnancy. Early Pregnancy: Biology and Medicine, 1997, 3: 1-6.
  
  12. Jaggi M, Mehrotra P. K., Maitra S. C., Agarwal S. L., Das K., and Kamboj V. P.. Ultrastructure of cellular components of human trophoblasts during early pregnancy. Reprod. Fertil. Dev., 1995, 7: 1529-1546.
  
  13. Jaggi M, Mehrotra P. K., Maitra S. C., Agarwal S. L., and Das K.. Role of intermediate cells in differentation of cyto to Syncytiotrophoblast during first trimester of human pregnancy. Proc. I.C.M.R. Young Scientist Symp on "Frontiers in Reproductive Biology", 1995, Bombay, February 10-11.
  
• Abstracts
  1. Jaggi M. and Balaji K. C. Protein Kinase D1 is Associated with Membrane Trafficking of Beta-catenin. 2006, Proc. Amer. Ass. Can. Res., Poster Presentation.
  
  2. Balaji K. C., Rao P. S., Jaggi M., Smith L. M., and Smith D. J. Induction of Metallothioneins is Associated with Resistance to Cisplatin and Radiation in Prostate Cancer Cells. 2005, Proc. Amer. Ass. Can. Res. Poster Presentation.
  
  3. Jaggi M. and Balaji K., C. Beta-catenin Interaction with PKD1/PKC mu and Nuclear Localization in Prostate Cancer. 2005, Prostate Cancer Symposium, American Society of Clinical Oncology, Poster Presentation.
  
  4. Jaggi M., Nazemi T., and Balaji K. C. Aberrant Expression of N-cadherin Correlates with Gleason Grade and Preoperative Serum Prostate Specific Antigen (PSA) in Prostate Cancer. 2005, Prostate Cancer Symposium, American Society of Clinical Oncology, Poster Presentation.
  
  5. Jaggi M. and Balaji K. C. E-cadherin Phosphorylation by PKD1/PKC mu is Associated with Altered Cell Aggregation and Motility in Prostate Cancer. 2005, Prostate Cancer Symposium, American Society of Clinical Oncology, Poster Presentation.
  
  6. Jaggi M., Nazemi T., and Balaji K. C. Bryostatin-1 Activates PKD1 and Increases Cellular Aggregation in Prostate Cancer. 2005, Prostate Cancer Symposium, American Society of Clinical Oncology, Poster Presentation.
  
  7. Smith D. J., Jaggi M., Rao P. S., Smith L. M., and Balaji K. C. Expression of Metallothioneins is Associated with Resistance to Both Cisplatin Chemotherapy and Radiation in Prostate Cancer Cells. 2005, American Urological Association Annual Meeting.
  
  8. Rao P. S., Lewis T., Smith D. J., Jaggi M., Balaji K. C., and Hemstreet G. P. Protein Kinase C mu/Protein Kinase D - Metallothionein 2A Interaction is Associated with Cisplatin Resistance in Prostate Cancer. 2004, SCS, AUA Annual Meeting, Poster Presentation.
  
  9. Lewis T., Milam T., Rao P. S., Jaggi M., Smith D. J., Hemstreet G. P., and Balaji K. C. Tissue Transglutaminase Interacts with a Kinase Anchor Protein 13 in Prostate Cancer. 2004, SCS, AUA Annual Meeting, Poster Presentation.
  
  10. Jaggi M., Hemstreet G. P., and Balaji K. C. Aberrant Expression of E-Cadherin, N-Cadherin and Beta-Catenin in Human Prostate Cancer (PC). 2004, SCS, AUA Annual Meeting, Poster Presentation.
  
  11. Jaggi M., Hemstreet G. P., and Balaji K. C. Protein Kinase C mu (PKC MU) Interacts with E-Cadherin and Beta-Catenin in Prostate Cancer (PC) In Vitro and In Vivo. 2004, SCS, AUA Annual Meeting, Poster Presentation.
  
  12. Jaggi M., Rao P. S., Smith D. J., Hemstreet G. P., and Balaji K. C. Protein Kinase C Mu (PKC MU) Interacts with E-Cadherin and Beta-Catenin in Prostate Cancer (PC) In Vitro and In Vivo. Proc. Amer. Ass. Can. Res. 2004, Vol 45, Abs.
  
  13. Jaggi M., Johansson S. L., Baker J. J., Rao P. S., Smith D. J., Hemstreet G. P., and Balaji K. C. Aberrant Expression of E-cadherin, N-cadherin and Beta-catenin in Human Prostate Cancer. 2004, Proc Amer Ass Can Res, Vol. 45, Abs. 2675.
  
  14. Smith D. J., Jaggi M., Rao P. S., Hemstreet G. P., and Balaji K. C.. A DNaseI Hypersensitive Site in the Promoter Region of the Human PKC Mu Gene. 2004, Proc Amer Ass Can Res, Vol. 45, Abs. 1577.
  
  15. Rao P. S., Jaggi M., and Balaji K. C.. Protein Kinase C Mu (PKC Mu) Interacts with Metallothionin2-A in Prostate Cancer. 2003, SCS, AUA, Annual Meeting, Abs. 97.
  
  16. Jaggi M., Balaji K. C., Wheelock M. J., and Johnson K. R. Activation of PKC by Phorbolester Results in the Formation of Adherens Junction in MDA-MB-453 Cells. 2003, Proc Amer Ass Can Res, Vol 44, Abs 1390.
  
  17. Jaggi M., Wheelock M. J., and Johnson K. R. Differential Displacement of Classical Cadherins by VE-Cadherin. 2001, Proc. The American Society for Cell Biology, Annual Meeting.
  
  18. Jaggi M., Basak S., and Das C. Hormonal Regulation of Integrins Statement in Mouse Blastocyst During Implantation. 1998, Proc. VII International Congress of Reproductive Immunology.
  
  19. Basak S., Jaggi M., and Das C. Stage Specific Statement of Integrins in Mouse Blastocyst During Implantation. 1998, Proc. VII International Congress of Reproductive Immunology.
  
  20. Jaggi M., Basak S., and Das C. Modulation of Integrin Statement by Steroid Hormones in Mouse Blastocyst .1998, 10th International Congress of Immunology.
  
  21. Jaggi M., Murthy P. S. R., and Mehrotra P. K. Statement of Cytokeratin and Vimentin in First Trimester Human Placenta Villi. 1998, Proc. International Conference. On Reproductive Health.
  
  22. Jaggi M. and Mehrotra P. K. First Trimester Human Trophoblasts in Culture to Test Pregnancy Interceptive In Vitro. 1997, Proc. Young Scientist Symposium on Reproductive Health Issues.
  
  23. Jaggi M., Mehrotra P. K., Maitra S. C., Agarwal S. L., and Das K. Gestation Age Dependent Changes in Surface Morphology of Human Chorionic Villi During Early Pregnancy. 1995, Proc. International Symposium on Prospects of Zona Pellucida Glycoproteins for Immunocontraception and 7th Annual Conference of Indian Society for the Study of Reproduction and Fertility.
  
  24. Jaggi M., Mehrotra P. K., Maitra S. C., Agarwal S. L., Das K., and Kamboj V. P. Ultrastructure of Cellular Components of Human Trophoblasts During Early Pregnancy. 1994, Placenta, Vol. 15A.34.
  
  25. Jaggi M., Maitra S. C., Agarwal S. L., Das K., and Mehrotra P. K. Ultrastructure of Human Trophoblasts of First Trimester Chorionic Villi. 1994, Proc. at the National Symposium on Reproductive Health Care.
  
  26. Jaggi M., Maitra S. C., Agarwal S. L., Das K., and Mehrotra P. K. Surface Morphology of Early Gestation Human Placental Villi. 1994, Proc. Endocrine Society of India, ESICON.