Education
- Ph.D., Microbiology - University of Pennsylvania, Philadelphia, PA
- B. Sci. Microbiology - University of Florida, Gainesville, FL
Experience
- Senior Scientist, Cardiovascular Research Center, South Dakota Health Research Foundation 6/04 -present
- Associate Professor, Basic Biomedical Sciences, Sanford School of Medicine, Sioux Falls, SD August 2004-present
- Assistant Professor, Basic Biomedical Sciences, Sanford School of MedicineSioux Falls, SD June-July 2004
- Assistant Professor, Department of Pathology, James H. Quillen College of Medicine, East Tennessee State University, Johnson City, TN, Sept. 1994-May 2004
- Instructor, Department of Pathology, James H. Quillen College of Medicine, East Tennessee State University, Johnson City, TN, March 1992-August 1993
- Research Specialist, Department of Pathology, James H. Quillen College of Medicine, East Tennessee State University, Johnson City, TN Sept. 1989- Feb. 1991
- Post-doctoral Research Fellow, Department of Microbiology, James Quillen College of Medicine, East Tennessee State University, Johnson City, TN March 1986-August 1989
Honors and Distinctions
- Grant Reviewer - Gastrointestinal Cell and Molecular Biology Study Section (10/04-present)
- Ad Hoc Reviewer, NIH-NHLBI, Myocardial Ischemia and Metabolism Study Group (10/05-present)
- Reviewer, NIH-NHLBI, Special Emphasis Panel for Program Project Grant (10/06)
- Fellow, American Heart Association-Basic Cardiovascular Sciences Council
- Member, International Society of Heart Research
- Manuscript Reviewer - Cardiovascular Research
- Manuscript Reviewer - Journal of Molecular and Cellular Cardiology
- Manuscript Reviewer - Critical Care Medicine
Awards
- NIH-NHLBI Grant 1RO1 HL077713-01 "Myocardial Ischemic Activation of the Akt Pathway" 7/04 - 6/08.
Research Focus
- Myocardial ischemia and the signal transduction pathways that mediate the endogenous cardio-protective mechanism- ischemic preconditioning. Specifically activation of the Akt/GSK-3 pathway during ischemia and the downstream substrates that are phosphorylated by this pathway.
Publications
- Armstrong SC and Schreiber AD 1985. Human monocyte recognition of complement-coated lymphoblastoid cells. J of Leukocyte Biol 37:161.
Armstrong SC and Ganote CE 1990. Effects of the phospholipase inhibitor mepacrine on irreversible injury in ischemic and metabolically inhibited adult isolated myocytes. Am J Path 138:545-555.
Armstrong SC and Ganote CE 1991. Effects of 2,3- butanedione monoxime (BDM) on contracture and injury of isolated rat myocytes following metabolic inhibition and ischemia. J Mol Cell Cardiol 23:1001
Armstrong SC and Ganote CE 1992. Flow cytometric analysis of isolated adult cardiomyocytes: Vinculin and tubulin fluorescence during metabolic inhibition and ischemia. J Mol Cell Cardiol 24:149-162.
Armstrong SC and Ganote CE 1992. Effects of the protein phosphatase inhibitors okadaic acid and calyculin A on metabolically inhibited and ischemic isolated myocytes. J Mol Cell Cardiol 24:869-884.
Ganote CE and Armstrong SC 1993. Ischemia and the myocyte cytoskeleton: Review and speculation. Cardiovasc Res. 27:1387-1403.
Ganote CE, Armstrong SC, Downey JM 1993. Adenosine and A1-selective agonists offer minimal protection against ischaemic injury to isolated rat cardiomyocytes. Cardiovasc Res. 27:1670-1676.
Armstrong SC, Downey JM, Ganote CE 1994. Preconditioning of isolated rabbit cardiomyocytes: Induction by metabolic stress and blockade by the adenosine antagonist SPT and calphostin C, a protein kinase C inhibitor.Cardiovasc Res 28:72-77.
Armstrong SC and Ganote CE 1994. Adenosine receptor specificity in preconditioning of isolated rabbit cardiomyocytes: Evidence of adenosine A3 receptor involvement. Cardiovasc Res 28:1049-1056.
Armstrong SC, and Ganote CE 1994. Preconditioning of isolated rabbit cardiomyocytes: Effects of glycolytic blockade, phorbol esters and ischaemia. Cardiovasc Res 28:1700-1706.
Armstrong SC and Ganote CE 1995. In vitro ischaemic preconditioning of isolated rabbit cardiomyocytes: Effects of selective adenosine receptor blockade and calphostin C. Cardiovasc Res 29:647-652.
Armstrong SC, Liu GS, Downey JM, and Ganote CE. 1995. Potassium channels and preconditioning of isolated rabbit cardiomyocytes: Effects of glyburide and pinacidil. J Mol Cell Cardiol 27:1765-1774.
Armstrong SC, Hoover DB, Delacey MH, Ganote CE 1996. Translocation of PKC, protein phosphatase inhibition and preconditioning of rabbit cardiomyocytes. J Mol Cell Cardiol, 28:1479-1492.
Rice PJ, Armstrong SC, Ganote CE 1996. Concentration-response relationships for adenosine agonists during preconditioning of rabbit cardiomyocytes. J Mol Cell Cardiol, 28:1355-1365.
Armstrong SC, Hoover DB, Shivell LC, Ganote CE, 1997. Preconditioning of isolated rabbit cardiomyocytes: No evident separation of induction, memory and protection. J Mol Cell Cardiol 29:2885-2298.
Armstrong SC, Kao R, Gao W, Shivell LM, Downey JM, Honkanen R, Ganote CE, 1997. Comparison of in vitro preconditioning responses of isolated pig and rabbit cardiomyocytes: Effects of a protein phosphatase inhibitor, fostriecin. J Mol Cell Cardiol. 29: 3009-3024.
Armstrong SC, Gao W, Lane JR, Ganote CE 1998. Protein phosphatase inhibitors calyculin A and fostriecin protect rabbit cardiomyocytes in late Ischemia. J Mol Cell Cardiol 30:61-71.
Weinbrenner C, Baines CP, Liu G-S, Armstrong SC, Ganote CE, Honkanen RE, Cohen MV, Downey JM. 1998. Fostriecin an inhibitor of protein phosphatase 2A, limits infarct size even when administered after onset of ischemia. Circulation 98:899-905.
Armstrong SC, Delacey M, Ganote CE. 1999. Phosphorylation state of HSP27 during preconditioning and protein phosphatase inhibitor protection of rabbit cardiomyocytes. J Mol Cell Cardiol. 31:555-567.
Armstrong SC, Shivell LC, Ganote CE. 2000. Differential translocation or phosphorylation of alpha B crystallin cannot be detected in ischemically preconditioned rabbit cardiomyocytes. J Mol Cell Cardiol 32:1301-1314.
Ganote CE and Armstrong SC. 2000. A brief review: Adenosine and preconditioning in the rat. Cardiovasc. Res. 45:134-140.
Armstrong SC, Shivell LC, Ganote CE. 2001. Sarcolemmal blebs and osmotic fragility as correlates of irreversible ischemic injury in preconditioned isolated rabbit cardiomyocytes. J Mol Cell Cardiol 33:149-160.
Armstrong SC, Shivell LC, Latham CA, Ganote CE. 2001. Ischemic loss of sarcolemmal dystrophin and spectrin : Correlation with myocardial injury. J Mol Cell Cardiol 33:1165-1179.
Ganote C and Armstrong S. 2002. Dystrophin associated protein complex and heart failure (commentary). Lancet 359:905-906.
Armstrong SC, Latham CA, Ganote CE. 2003. An ischemic b-dystroglycan degradation product: Correlation with irreversible injury in adult rabbit cardiomyocytes. Mol Cell Biochem 242:71-79.
Diaz RJ, Armstrong SC, Battish M, Backx PH, Ganote CE, Wilson GJ. 2003. Enhanced cell volume regulation: A key protective mechanism of ischemic preconditioning in rabbit ventricular myocytes. J Mol Cell Cardiol 35:45-58.
Ganote CE and Armstrong SC. 2003. Effects of CCCP-induced mitochondrial uncoupling and cyclosporin A on cell volume, cell injury and preconditioning protection of isolated rabbit cardiomyocytes. J Mol Cell Cardiol 35:749-759.
Armstrong, SC. 2004. Protein kinase activation and myocardial ischemia/reperfusion injury. (Invited Review) Cardiovasc Res 61: 427-436.
Armstrong, SC, 2004. Anti-oxidants and apoptosis: Attenuation of doxorubicin induced cardiomyopathy by carvedilol (Invited Editorial) J Mol Cell Cardiol 37:817-821.
Armstrong, SC 2006. Pharmacologic preconditioning with an A3 adenosine receptor agonist enhances the myocardial ischemic phosphorylation of Akt and GSK-3. Am J. Physiol. (Manuscript in preparation).
Armstrong, SC 2006. ERK dual phosphorylation is negatively regulated by ischemic p38 MAPK activation in adult rabbit cardiomyocytes. Am J. Physiol. (Manuscript in preparation).
Armstrong SC, Scott MA, Graber KR, Redetzke R, Donohue E, Eslinger A, Gerdes MA. 2006. Transverse (T)-tubular localization of the dystrophin associated protein complex and dilated cardiomyopathy Circ Res (Manuscript in preparation).
- Books and Chapters
Ganote CE and Armstrong SC 1996. Ischemic injury and preconditioning in a model of isolated cardiomyocytes. In : Purines and Myocardial Protection, A.-S. Abd-Elfattah, A. S. Wechsler(Eds) Norwell MA, Kluwer Academic Publishers pp 481-498.
Ganote CE and Armstrong SC (2003) Is reduced cell swelling a plausible end effector of ischemic preconditioning protection? In: Myocardial Ischemia and Preconditioning, N.S. Dhalla, N. Takeda, M. Singh, A. Lukas (Eds) Norwell MA, Kluwer Academic Publishers, pp 181-188.
Armstrong, SC 2006. Analysis of MAP kinase activation. In: Mast Cells: Methods and Protocols, G. Krishnaswamy and DS Chi (Eds) Humana Press 315:151-163
|
