Subhash.Chauhan@usd.edu

Education
• Ph.D. (1997) Major Reproductive Endocrinology
  Title: "Studies on cytological and molecular mechanism of an anti-implantation action of a triphenylethylene antiestrogen Centchroman in Rat" from Central Drug Research Institute (CDRI), Lucknow, India.
• M.S: (1990) Zoology, with Honors from H.N.B. Garhwal University, Shrinagar, Garhwal, India.
• B.Sc: (1987) Zoology, Botany and Chemistry from H.N.B. Garhwal University, Shrinagar, Garhwal, India.

Professional Experience:
• Research Scientist, Cancer Biology Research Center, Sanford Research/USD, Sioux Falls, SD, December 2005 to present  
• Assistant Professor, Department of OB/GYN, Basic Biomedical Sciences, Sanford School of Medicine of the University of South Dakota School, Sioux Falls, SD, 2006 to present
• Research Associate, Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center (UNMC) June 2004 to December 2005
• Post Doctoral Fellow, Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center (UNMC) June 2001to May 2004
• Post Doctoral Research Associate, Department of OB /GYN, Medical College of Ohio (MCO) June 1999 to May 2001
• Scientific Officer (Electron Microscopy), Department of Pathology, Sanjay Gandhi Post Graduate Institute of Medical Sciences (SGPGIMS), Lucknow, India., 1998 - 1999
• Research Associate, Department of Endocrinology, SGPGIMS, Lucknow, India., 1997 - 1998
• Senior Research Fellow (SRF), Division of Endocrinology CDRI, Lucknow, India., 1995 – 1997
• Junior Research Fellow (JRF), Division of Endocrinology CDRI, Lucknow, India., 1992 – 1995

Member of Professional Society:
• American Association for Cancer Research (AACR)
• American Association for Advancement of Science (AAAS)

Honors and Awards:
• 1. Qualified National Eligibility Test (NET) for Lecturer ship conducted by CSIR-UGC, New Delhi, India 1990.
• 2. Qualified NET for Junior Research Fellowship & Lecturer ship conducted by CSIR-UGC, New Delhi, India 1991.
• 3. Research Associate awarded by Indian Council of Medical Research (ICMR), 1997.
• 4. Research Associate awarded by Council for Scientific & Industrial Research (CSIR), 1998.

Research Interest:
• Identification and Characterization of Diagnostic and Therapeutic Targets for Gynecological Malignancies (ovarian, cervical and endometrial cancer)

Publications
• Chauhan SC., Singh AP., Ruiz F., Johannson SL., Jain M., Smith L., Moniaux N. and Batra SK. Aberrant expression of MUC4 in ovarian cancer: Diagnostic significance alone and in combination with MUC1 and MUC16. Modern Pathology (Accepted)
  
  Andrianifahanana M., Chauhan SC., Moniaux N. and Batra SK.  Analysis of Cytokine Expression in Pancreatic Adenocarcinomas:  Association with MUC4 Mucin expression and potential pathobiologic implications. American Journal of Gastroenterology (Accepted).
  
  Singh AP., Chauhan SC., Andrianifahanana M., Moniaux N., Meza JL., Copin MC., Hollingsworth MA., Aubert JP. and Batra SK. Inverse association of CFTR and MUC4 in pancreatic adenocarcinoma cells:  Regulation of MUC4 by transcriptional and post-translational mechanisms. (Oncogene) (Accepted)
  
  Moniaux N., Nemos C., Schmied BM., Chauhan SC., Deb S., Morikane K., Choudhury A., Vanlith M., Sutherlin M., Sikela JM., Hollingsworth MA and Batra SK. The human homologue of the RNA polymerase II-associated factor 1 (hPaf1), localized on the 19q13 amplicon, is associated with tumorigenesis. Oncogene 1;25(23):3247-57
  
  Singh AP., Chauhan SC., Johansson SL., Lin MF., and Batra SK. Aberrant expression of transmembrane mucins, MUC1 and MUC4 in human prostate carcinomas and cell lines. The Prostate 2006 1;66(4):421-9.
  
   Jain M., Chauhan SC., Singh AP., Venketraman G., Colcher D., and Batra SK. Penetratin improves tumor retention of single-chain antibodies: A novel step towards optimization of radioimmunotherapy of solid tumors. Cancer Research 1;65 (17):7840-6 2005.
  
  Chauhan SC., Jain M., Moore E.D., Wittel UA., Li J., Gwilt PR., Colcher D., and Batra SK.  Pharmacokinetic and biodistribution of 177Lu-labeled multivalent single chain Fv construct of monoclonal antibody CC49 European J. Nuclear Medicine and Mol Imaging 32: 264-73 2005.
  
  Wittel UA., Jain M., Goel A., Chauhan SC., and Batra SK. The in vivo characteristics of genetically engineered divalent and tetravalent single chain antibody constructs. J. Nuclear Medicine and Biology 32: 157-64 2005.
  
  Wittel UA., Jain M., Goel A., Baranowska-Kortylewicz  J.,  Kurizaki T., Chauhan SC., Agrawal DK,. Colcher D., and Batra, SK.  Engineering and characterization of a divalent single-chain Fv angiotensin II fusion construct of monoclonal antibody CC49. Biochem Biophys Res Commun. 329(1):168-76 2005.
  
  Moniaux, N., Varshney GC., Chauhan, SC., Copin, MC., Jain, M., Wittel, UA., Andrianifahanana, M., Aubert, JP., and Batra, SK.   Generation and characterization of anti-MUC4 monoclonal antibodies reactive with normal and cancer cells in humans. J Histochem Cytochem. 52(2):253-61. 2004.
  
  Singh, A.P., Moniaux, N., Chauhan, SC., Meza JL., and Batra SK. Inhibition of MUC4 expression suppresses pancreatic tumor cell growth and metastasis. Cancer Research 64:622-630 2004.
  
  Batra SK., Jain M., Wittel UA., Chauhan SC., and Colcher D. Pharmacokinetics and biodistribution of genetically engineered antibodies. Curr Opin Biotechnol. 13(6):603-8 2002.
  
  Standop J., Schneider MB., Ulrich A., Chauhan SC., Moniaux N., Bichler MW., Batra SK., and Pour PM. The pattern of xenobiotic-metabolizing enzymes in the human pancreas. J. Toxicol. Environ. Health, 65(19):1379-400, 2002
  
  Naz RK. and Chauhan SC. Human sperm-specific Peptide vaccine that causes long-term reversible contraception. Biol Reprod. 67(2):674-80 2002
  
  Chauhan SC. and Naz RK.  Effect of antibodies to sperm specific recombinant contraceptive vaccinogen (rCV) on murine fertilization: Search for an animal model to examine its contraceptive potential. Molecular Reproduction and Development 60(3):425-32 2001.

Research Support
• Ongoing Research Support:
  U01 CA114642                 10/1/05 – 4/30/08
  NIH/NCI- Regional Native American Community Network Program, Human Papilloma Virus in American Indian and White Women:  Epidemiology and Risk Factors